There are a number of ways to increase your profit margin by opening an online store. You may want to focus on a specific, niche market. For example, if you have a business related to health and fitness products, then you will not want to open an ecommerce store that caters to high-end consumers with disposable income. You will need to be focused on a specific, niche market, such as those who want to lose weight or treat acne. In addition to focusing on a particular market, you can also expand your product line and offer more competitive prices.